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POINT  

Protein Structure Guided Local Test
View on CRAN: Click here


Download and install POINT package within the R console
Install from CRAN:
install.packages("POINT")

Install from Github:
library("remotes")
install_github("cran/POINT")

Install by package version:
library("remotes")
install_version("POINT", "1.4")



Attach the package and use:
library("POINT")
Maintained by
Shannon T. Holloway
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2019-03-05
Latest Update: 2025-05-04
Description:
Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) .
How to cite:
Shannon T. Holloway (2019). POINT: Protein Structure Guided Local Test. R package version 1.4, https://cran.r-project.org/web/packages/POINT. Accessed 07 Mar. 2026.
Previous versions and publish date:
1.1 (2019-03-05 19:50), 1.2 (2022-06-07 01:10), 1.3 (2023-10-01 20:00)
Other packages that cited POINT R package
View POINT citation profile
Other R packages that POINT depends, imports, suggests or enhances
Complete documentation for POINT
Functions, R codes and Examples using the POINT R package
Some associated functions: POINT-package . point . 
Some associated R codes: A_BurdenKernel.R . A_Kernel.R . A_LinearKernel.R . A_PolyKernel.R . B_PvMethod.R . B_PvMethod_Davies.R . B_PvMethod_Liu.R . C_BinomialTrait.R . C_GaussianTrait.R . D_NullResult.R . calcLocalKernel.R . distanceMatrix.R . mainCode.R . point.R . pvResamp.R .  Full POINT package functions and examples
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