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rema  

Rare Event Meta Analysis
View on CRAN: Click here


Download and install rema package within the R console
Install from CRAN:
install.packages("rema")

Install from Github:
library("remotes")
install_github("cran/rema")

Install by package version:
library("remotes")
install_version("rema", "0.0.1")



Attach the package and use:
library("rema")
Maintained by
Brinley N. Zabriskie
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2021-10-28
Latest Update: 2021-10-28
Description:
The rema package implements a permutation-based approach for binary meta-analyses of 2x2 tables, founded on conditional logistic regression, that provides more reliable statistical tests when heterogeneity is observed in rare event data (Zabriskie et al. 2021 ). To adjust for the effect of heterogeneity, this method conditions on the sufficient statistic of a proxy for the heterogeneity effect as opposed to estimating the heterogeneity variance. While this results in the model not strictly falling under the random-effects framework, it is akin to a random-effects approach in that it assumes differences in variability due to treatment. Further, this method does not rely on large-sample approximations or continuity corrections for rare event data. This method uses the permutational distribution of the test statistic instead of asymptotic approximations for inference. The number of observed events drives the computation complexity for creating this permutational distribution. Accordingly, for this method to be computationally feasible, it should only be applied to meta-analyses with a relatively low number of observed events. To create this permutational distribution, a network algorithm, based on the work of Mehta et al. (1992) and Corcoran et al. (2001) , is employed using C++ and integrated into the package.
How to cite:
Brinley N. Zabriskie (2021). rema: Rare Event Meta Analysis. R package version 0.0.1, https://cran.r-project.org/web/packages/rema. Accessed 26 Oct. 2026.
Previous versions and publish date:
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Other packages that cited rema R package
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Complete documentation for rema
Functions, R codes and Examples using the rema R package
Some associated functions: plot.rema . rema . 
Some associated R codes: CI.R . CMLE.R . FINDROOT.R . MUE.R . RcppExports.R . rema-package.R . rema.R . rema_generics.R . rema_inference.R . strings.R .  Full rema package functions and examples
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