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nlmixr2est  

Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines
View on CRAN: Click here


Download and install nlmixr2est package within the R console
Install from CRAN:
install.packages("nlmixr2est")

Install from Github:
library("remotes")
install_github("cran/nlmixr2est")

Install by package version:
library("remotes")
install_version("nlmixr2est", "7.1.0")



Attach the package and use:
library("nlmixr2est")
Maintained by
Matthew Fidler
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2022-05-12
Latest Update: 2025-07-25
Description:
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).
How to cite:
Matthew Fidler (2022). nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines. R package version 7.1.0, https://cran.r-project.org/web/packages/nlmixr2est. Accessed 07 Oct. 2026.
Previous versions and publish date:
(2026-09-20 07:10), 2.0.6 (2022-05-12 09:50), 2.0.7 (2022-05-23 14:10), 2.0.8 (2022-06-22 10:00), 2.1.0 (2022-10-19 22:02), 2.1.1 (2022-10-22 15:12), 2.1.2 (2022-11-02 09:17), 2.1.3 (2022-11-10 18:00), 2.1.4 (2023-04-02 10:20), 2.1.5 (2023-04-22 21:50), 2.1.6 (2023-05-26 01:20), 2.1.7 (2023-09-19 01:10), 2.1.8 (2023-10-08 06:40), 2.2.0 (2023-12-12 12:20), 2.2.1 (2024-01-31 06:10), 2.2.2 (2024-05-28 21:20), 3.0.0 (2024-09-18 17:10), 3.0.1 (2024-10-23 01:20), 3.0.2 (2024-11-23 06:50), 3.0.3 (2025-01-18 18:50), 3.0.4 (2025-02-19 01:40), 4.0.0 (2025-07-16 01:40), 4.0.1 (2025-07-20 01:20), 4.0.2 (2025-07-25 02:20), 4.1.0 (2025-08-29 21:40), 4.1.1 (2025-10-09 07:10), 5.0.2 (2025-11-28 20:20), 6.0.0 (2026-05-31 07:30), 6.0.1 (2026-06-03 11:10), 7.0.2 (2026-08-04 22:50)
Other packages that cited nlmixr2est R package
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Other R packages that nlmixr2est depends, imports, suggests or enhances
Complete documentation for nlmixr2est
Functions, R codes and Examples using the nlmixr2est R package
Some associated functions: addCwres . addNpde . addTable . assertNlmixrFit . assertNlmixrFitData . bobyqaControl . boxCox . cholSE . dot-foceiPreProcessData . dot-nlmFinalizeList . dot-nlmFreeEnv . dot-nlmSetupEnv . dot-nlmixr2estLastPredSimulationInfo . dot-nlmixr2objectNameAssign . dot-nlmixrNlmFunC . dot-nlmixrNlmeFun . dot-nlmixrNlminbFunC . dot-nlmixrNlsData . dot-nlmixrNlsFun . dot-nlmixrNlsFunVal . dot-nlmixrOptimFunC . dot-rxGetDVFTransform . dot-saemDropMuRefFromModel . dot-uiApplyMu2 . dot-uiFinalizeMu2 . foceiControl . foceiFitCpp_ . getBaseSimModelFit . getValidNlmixrControl . lbfgsb3cControl . n1qn1Control . newuoaControl . nlmControl . nlminbControl . nlmixr2 . nlmixr2AllEst . nlmixr2AugPredSolve . nlmixr2CreateOutputFromUi . nlmixr2Est . nlmixr2Gill83 . nlmixr2GradFun . nlmixr2Hess . nlmixr2Keywords . nlmixr2Logo . nlmixr2NlmeControl . nlmixr2Print . nlmixr2Validate . nlmixr2Version . nlmixrAddObjectiveFunctionDataFrame . nlmixrAddTiming . nlmixrCbind . nlmixrClone . nlmixrUpdateObject . nlmixrWithTiming . nlsControl . nmGetDistributionSaemLines . nmNearPD . nmObjGet . nmObjGetControl . nmObjGetData . nmObjGetEstimationModel . nmObjGetFoceiControl . nmObjGetIpredModel . nmObjGetPredOnly . nmObjGetRxSolve . nmObjHandleControlObject . nmObjHandleModelObject . nmObjUiSetCompressed . nmSuppressMsg . nmsimplex . ofv . optimControl . print.saemFit . reexports . residuals.nlmixr2FitData . rxGetDistributionFoceiLines . rxGetDistributionNlmeLines . rxGetDistributionNlsLines . saemControl . setCov . setOfv . sqrtm . summary.saemFit . tableControl . uobyqaControl . vpcNameDataCmts . vpcSim . vpcSimExpand . 
Some associated R codes: RcppExports.R . addCwres.R . asFunction.R . assert.R . augPred.R . bobyqa.R . broom.R . cloneNlmixr.R . coerce.R . complete.R . cov.R . fitSim.R . focei.R . foceiControl.R . ini.R . lbfgsb3c.R . md5.R . model.R . mu2.R . n1qn1.R . newuoa.R . nlm.R . nlmShared.R . nlme.R . nlmeRxUiGet.R . nlminb.R . nlmixr2.R . nlmixr2Est.R . nlmixr2Keywords.R . nlmixr2_md5.R . nlmixr2output.R . nlmixrAddObjectiveFunction.R . nlmixrCbind.R . nlmixrGrad.R . nlmixrUpdateObject.R . nls.R . nmObjGet.R . nmObjHandle.R . npde.R . ofv.R . onLoad.R . optim.R . pkpars.R . preProcessModel.R . print.R . reexports.R . resid.R . rxPipeline.R . rxsolve.R . saem.R . saemControl.R . saemRxUiGet.R . saemRxUiGetModel.R . saem_fit.R . saem_fit_aux.R . sharedControl.R . simulate.R . sourceCppFunction.R . splitModelRxUiGet.R . timing.R . uobyqa.R . update.R . utils.R . validate.R . vpc.R .  Full nlmixr2est package functions and examples
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