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httk
View on CRAN: Click
here
Download and install httk package within the R console
Install from CRAN:
install.packages("httk")
Install from Github:
library("remotes")
install_github("cran/httk") Install by package version:
library("remotes")
install_version("httk", "2.7.4") Attach the package and use:
library("httk")
Maintained by
John Wambaugh
[Scholar Profile | Author Map]
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2015-03-06
Latest Update: 2025-08-25
Description:
Pre-made models that can be rapidly tailored to various chemicals
and species using chemical-specific in vitro data and physiological
information. These tools allow incorporation of chemical
toxicokinetics ("TK") and in vitro-in vivo extrapolation ("IVIVE")
into bioinformatics, as described by Pearce et al. (2017)
(). Chemical-specific
in vitro data characterizing toxicokinetics have been obtained
from relatively high-throughput experiments. The
chemical-independent ("generic") physiologically-based ("PBTK") and empirical
(for example, one compartment) "TK" models included here can be
parameterized with in vitro data or in silico predictions which are
provided for thousands of chemicals, multiple exposure routes,
and various species. High throughput toxicokinetics ("HTTK") is the
combination of in vitro data and generic models. We establish the
expected accuracy of HTTK for chemicals without in vivo data
through statistical evaluation of HTTK predictions for chemicals
where in vivo data do exist. The models are systems of ordinary
differential equations that are developed in MCSim and solved
using compiled (C-based) code for speed. A Monte Carlo sampler is
included for simulating human biological variability
(Ring et al., 2017 )
and propagating parameter uncertainty
(Wambaugh et al., 2019 ).
Empirically calibrated methods are included for predicting
tissue:plasma partition coefficients and volume of distribution
(Pearce et al., 2017 ).
These functions and data provide a set of tools for using IVIVE to
convert concentrations from high-throughput screening experiments
(for example, Tox21, ToxCast) to real-world exposures via reverse
dosimetry (also known as "RTK")
(Wetmore et al., 2015 ).
How to cite:
John Wambaugh (2015). httk: High-Throughput Toxicokinetics. R package version 2.7.4, https://cran.r-project.org/web/packages/httk. Accessed 07 Mar. 2026.
Previous versions and publish date:
1.1 (2015-03-06 17:47), 1.2 (2015-05-11 16:53), 1.3 (2015-10-14 09:53), 1.4 (2016-02-03 01:14), 1.5 (2017-03-03 18:16), 1.6 (2017-06-08 18:55), 1.7 (2017-07-15 08:28), 1.8 (2018-01-23 22:54), 1.9.1 (2019-04-17 21:00), 1.9.2 (2019-04-25 18:10), 1.9 (2019-02-04 21:33), 1.10.0 (2019-07-12 00:21), 1.10.1 (2019-09-10 06:30), 2.0.0 (2020-02-17 07:10), 2.0.1 (2020-03-02 07:00), 2.0.2 (2020-07-19 15:50), 2.0.3 (2020-09-25 13:00), 2.0.4 (2021-05-10 09:50), 2.1.0 (2022-03-26 02:20), 2.2.0 (2022-09-08 23:32), 2.2.1 (2022-09-24 07:40), 2.2.2 (2023-02-20 23:40), 2.3.0 (2023-12-08 19:50), 2.3.1 (2024-03-27 01:00), 2.4.0 (2024-09-06 00:40), 2.5.0 (2025-01-14 08:00), 2.6.0 (2025-04-20 06:30), 2.6.1 (2025-05-01 21:40), 2.7.0 (2025-07-23 22:40), 2.7.1 (2025-08-21 16:00), 2.7.2 (2025-08-29 11:50), 2.7.3 (2025-09-12 17:00)
Other packages that cited httk R package
View httk citation profile
Other R packages that httk depends,
imports, suggests or enhances
Complete documentation for httk
Functions, R codes and Examples using
the httk R package
Some associated functions: CAS.checksum . EPA.ref . Frank2018invivo . Obach2008 . Tables.Rdata.stamp . Wetmore2012 . add_chemtable . age_draw_smooth . apply_clint_adjustment . apply_fup_adjustment . armitage_estimate_sarea . armitage_eval . armitage_input . augment.table . available_rblood2plasma . aylward2014 . benchmark_httk . blood_mass_correct . blood_weight . bmiage . body_surface_area . bone_mass_age . brain_mass . calc_analytic_css . calc_analytic_css_1comp . calc_analytic_css_3comp . calc_analytic_css_3compss . calc_analytic_css_pbtk . calc_css . calc_dow . calc_elimination_rate . calc_fbio.oral . calc_fetal_phys . calc_fup_correction . calc_half_life . calc_hep_bioavailability . calc_hep_clearance . calc_hep_fu . calc_hepatic_clearance . calc_ionization . calc_kair . calc_krbc2pu . calc_ma . calc_maternal_bw . calc_mc_css . calc_mc_oral_equiv . calc_mc_tk . calc_rblood2plasma . calc_stats . calc_tkstats . calc_total_clearance . calc_vdist . chem.invivo.PK.aggregate.data . chem.invivo.PK.data . chem.invivo.PK.summary.data . chem.physical_and_invitro.data . ckd_epi_eq . concentration_data_Linakis2020 . convert_httkpop_1comp . convert_solve_x . convert_units . create_mc_samples . dawson2021 . estimate_gfr . estimate_gfr_ped . estimate_hematocrit . example.seem . example.toxcast . export_pbtk_jarnac . export_pbtk_sbml . fetalpcs . gen_age_height_weight . gen_height_weight . gen_serum_creatinine . get_caco2 . get_chem_id . get_cheminfo . get_clint . get_fabsgut . get_fup . get_gfr_category . get_invitroPK_param . get_lit_cheminfo . get_lit_css . get_lit_oral_equiv . get_physchem_param . get_rblood2plasma . get_weight_class . get_wetmore_cheminfo . get_wetmore_css . get_wetmore_oral_equiv . hct_h . hematocrit_infants . honda.ivive . honda2023.data . honda2023.qspr . howgate . httk-package . httk.performance . httkpop . httkpop_biotophys_default . httkpop_direct_resample . httkpop_direct_resample_inner . httkpop_generate . httkpop_mc . httkpop_virtual_indiv . hw_H . in.list . invitro_mc . is.httk . is_in_inclusive . johnson . kapraun2019 . kidney_mass_children . liver_mass_children . load_dawson2021 . load_honda2023 . load_pradeep2020 . load_sipes2017 . lump_tissues . lung_mass_children . mcnally_dt . mecdt . metabolism_data_Linakis2020 . monte_carlo . onlyp . pancreas_mass_children . parameterize_1comp . parameterize_3comp . parameterize_fetal_pbtk . parameterize_gas_pbtk . parameterize_pbtk . parameterize_schmitt . parameterize_steadystate . pc.data . pearce2017regression . pharma . physiology.data . pksim.pcs . pradeep2020 . predict_partitioning_schmitt . pregnonpregaucs . propagate_invitrouv_1comp . propagate_invitrouv_3comp . propagate_invitrouv_pbtk . r_left_censored_norm . reset_httk . rfun . rmed0non0u95 . scale_dosing . scr_h . set_httk_precision . sipes2017 . skeletal_muscle_mass . skeletal_muscle_mass_children . skin_mass_bosgra . solve_1comp . solve_3comp . solve_fetal_pbtk . solve_gas_pbtk . solve_model . solve_pbtk . spleen_mass_children . supptab1_Linakis2020 . supptab2_Linakis2020 . tissue.data . tissue_masses_flows . tissue_scale . wambaugh2019.nhanes . wambaugh2019 . wambaugh2019.raw . wambaugh2019.seem3 . wambaugh2019.tox21 . wang2018 . well_param . wfl .
Some associated R codes: add_chemtable.R . age_draw_smooth.R . apply_clint_adjustment.R . apply_fup_adjustment.R . armitage.R . available_rblood2plasma.R . benchmark_httk.R . calc_analytic_css.R . calc_analytic_css_1comp.R . calc_analytic_css_3comp.R . calc_analytic_css_3compss.R . calc_analytic_css_pbtk.R . calc_css.R . calc_elimination_rate.R . calc_fetal_phys.R . calc_fup_correction.R . calc_half_life.R . calc_hep_bioavailability.R . calc_hep_clearance.R . calc_hep_fu.R . calc_kair.R . calc_krbc2pu.R . calc_ma.R . calc_maternal_bw.R . calc_mc_css.R . calc_mc_oral_equiv.R . calc_mc_tk.R . calc_oral_bioavailability.R . calc_rblood2plasma.R . calc_timecourse_peak.R . calc_tkstats.R . calc_total_clearance.R . calc_volume_of_distribution.R . ckd_epi_eq.R . convert_httkpop_1comp.R . convert_solve_x.R . convert_units.R . create_mc_samples.R . data.R . do_initial_dose_pbtk.R . estimate_gfr.R . estimate_gfr_ped.R . estimate_hematocrit.R . export_pbtk_jarnac.R . export_pbtk_sbml.R . gen_age_height_weight.R . gen_height_weight.R . gen_serum_creatinine.R . get_caco2.R . get_chem_id.R . get_cheminfo.R . get_clint.R . get_fabsgut.R . get_fup.R . get_gfr_category.R . get_invitroPK_param.R . get_lit_cheminfo.R . get_lit_css.R . get_lit_oral_equiv.R . get_physchem_param.R . get_rblood2plasma.R . get_weight_class.R . globals.R . hematocrit_infants.R . honda.ivive.R . httk-package.R . httkpop_biotophys_default.R . httkpop_direct_resample.R . httkpop_direct_resample_inner.R . httkpop_generate.R . httkpop_mc.R . httkpop_virtual_indiv.R . in.list.R . inhalation_inits.R . invitro_mc.R . ionization_functions.R . load_dawson2021.R . load_honda2023.R . load_pradeep2020.R . load_sipes2017.R . lump_tissues.R . modelinfo_1comp.R . modelinfo_3comp.R . modelinfo_3compss.R . modelinfo_fetal_pbtk.R . modelinfo_gas_pbtk.R . modelinfo_pbtk.R . modelinfo_schmitt.R . monte_carlo.R . parameterize_1comp.R . parameterize_3comp.R . parameterize_fetal_pbtk.R . parameterize_gas_pbtk.R . parameterize_pbtk.R . parameterize_schmitt.R . parameterize_steadystate.R . predict_partitioning_schmitt.R . propagate_invitrouv_1comp.R . propagate_invitrouv_3comp.R . propagate_invitrouv_pbtk.R . r_left_censored_norm.R . reset_httk.R . rmed0non0u95.R . scale_dosing.R . set_httk_precision.R . solve_1comp.R . solve_3comp.R . solve_fetal_pbtk.R . solve_gas_pbtk.R . solve_model.R . solve_pbtk.R . tissue_mass_functions.R . tissue_masses_flows.R . tissue_scale.R . utils.R . zzz.R . Full httk package functions and examples
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