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drugdevelopR  

Utility-Based Optimal Phase II/III Drug Development Planning
View on CRAN: Click here


Download and install drugdevelopR package within the R console
Install from CRAN:
install.packages("drugdevelopR")

Install from Github:
library("remotes")
install_github("cran/drugdevelopR")

Install by package version:
library("remotes")
install_version("drugdevelopR", "1.0.1")



Attach the package and use:
library("drugdevelopR")
Maintained by
Lukas D. Sauer
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2024-01-10
Latest Update: 2024-01-10
Description:
Plan optimal sample size allocation and go/no-go decision rules for phase II/III drug development programs with time-to-event, binary or normally distributed endpoints when assuming fixed treatment effects or a prior distribution for the treatment effect, using methods from Kirchner et al. (2016) and Preussler (2020). Optimal is in the sense of maximal expected utility, where the utility is a function taking into account the expected cost and benefit of the program. It is possible to extend to more complex settings with bias correction (Preussler S et al. (2020) ), multiple phase III trials (Preussler et al. (2019) ), multi-arm trials (Preussler et al. (2019) ), and multiple endpoints (Kieser et al. (2018) ).
How to cite:
Lukas D. Sauer (2024). drugdevelopR: Utility-Based Optimal Phase II/III Drug Development Planning. R package version 1.0.1, https://cran.r-project.org/web/packages/drugdevelopR. Accessed 21 Nov. 2024.
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Complete documentation for drugdevelopR
Functions, R codes and Examples using the drugdevelopR R package
Some associated functions: EPsProg23 . EPsProg23_binary . EPsProg23_normal . EPsProg_bias . EPsProg_bias_binary . EPsProg_bias_normal . EPsProg_multiple_normal . EPsProg_multiple_tte . EPsProg_multitrial . EPsProg_multitrial_binary . EPsProg_multitrial_normal . EPsProg_tte . Ed3_bias . Ed3_tte . En3_bias_binary . En3_bias_normal . Epgo23 . Epgo23_binary . Epgo23_normal . Epgo_bias . Epgo_bias_binary . Epgo_bias_normal . Epgo_tte . Ess_binary . Ess_multiple_normal . Ess_multiple_tte . Ess_normal . Ess_tte . PsProg_binary . PsProg_normal . PsProg_tte . d3_skipII_tte . dbivanorm . drugdevelopR . drugdevelopResult . fmax . fmin . get_sample_multiple_normal . get_sample_multiple_tte . optimal_bias . optimal_bias_binary . optimal_bias_generic . optimal_bias_normal . optimal_binary . optimal_binary_generic . optimal_generic . optimal_multiarm . optimal_multiarm_binary . optimal_multiarm_generic . optimal_multiarm_normal . optimal_multiple_generic . optimal_multiple_normal . optimal_multiple_tte . optimal_multitrial . optimal_multitrial_binary . optimal_multitrial_generic . optimal_multitrial_normal . optimal_normal . optimal_normal_generic . optimal_return_doc . optimal_tte . optimal_tte_generic . os_tte . pgo_binary . pgo_multiple_normal . pgo_multiple_tte . pgo_normal . pgo_tte . posp_normal . print.drugdevelopResult . print_drugdevelopResult_helper . prior_tte . pw . ss_binary . ss_normal . ss_tte . utility23 . utility23_binary . utility23_normal . utility_bias . utility_bias_binary . utility_bias_normal . utility_multiarm . utility_multiarm_binary . utility_multiarm_normal . utility_multiple_normal . utility_multiple_tte . utility_multitrial . utility_multitrial_binary . utility_multitrial_normal . utility_tte . 
Some associated R codes: drugdevelopR.R . drugdevelopResult.R . function_bias_binary.R . function_bias_normal.R . functions_bias.R . functions_binary.R . functions_multiarm.R . functions_multiarm_binary.R . functions_multiarm_normal.R . functions_multiple_normal.R . functions_multiple_tte.R . functions_multitrial.R . functions_multitrial_binary.R . functions_multitrial_normal.R . functions_normal.R . functions_tte.R . optimal_bias.R . optimal_bias_binary.R . optimal_bias_generic.R . optimal_bias_normal.R . optimal_binary.R . optimal_binary_generic.R . optimal_generic.R . optimal_multiarm.R . optimal_multiarm_binary.R . optimal_multiarm_generic.R . optimal_multiarm_normal.R . optimal_multiple_generic.R . optimal_multiple_normal.R . optimal_multiple_tte.R . optimal_multitrial.R . optimal_multitrial_binary.R . optimal_multitrial_generic.R . optimal_multitrial_normal.R . optimal_normal.R . optimal_normal_generic.R . optimal_return_doc.R . optimal_tte.R . optimal_tte_generic.R . print.drugdevelopResult.R .  Full drugdevelopR package functions and examples
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