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wnl  

Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis
View on CRAN: Click here


Download and install wnl package within the R console
Install from CRAN:
install.packages("wnl")

Install from Github:
library("remotes")
install_github("cran/wnl")

Install by package version:
library("remotes")
install_version("wnl", "0.8.4")



Attach the package and use:
library("wnl")
Maintained by
Kyun-Seop Bae
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2017-10-16
Latest Update: 2025-03-23
Description:
This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.
How to cite:
Kyun-Seop Bae (2017). wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis. R package version 0.8.4, https://cran.r-project.org/web/packages/wnl. Accessed 25 Aug. 2026.
Previous versions and publish date:
(2026-07-26 09:50), 0.3.1 (2017-10-16 13:17), 0.3.2 (2017-12-01 05:49), 0.3.3 (2018-03-02 06:19), 0.4.0 (2018-04-02 23:55), 0.4.1 (2018-06-14 13:42), 0.5.0 (2019-05-10 07:50), 0.5.1 (2019-06-10 18:00), 0.6.0 (2020-07-16 06:30), 0.6.1 (2020-08-27 18:10), 0.6.2 (2021-08-07 11:50), 0.6.3 (2021-09-06 06:30), 0.6.4 (2021-11-22 11:20), 0.7.0 (2022-10-28 11:20), 0.7.1 (2022-11-30 01:10), 0.7.2 (2023-03-26 11:00), 0.7.3 (2023-04-25 05:30), 0.8.0 (2024-02-22 07:20), 0.8.1 (2024-06-01 05:10), 0.8.2 (2025-02-21 09:00), 0.8.3 (2025-03-23 04:50), 0.8.4 (2025-09-08 01:30), 0.8.5 (2026-03-07 17:00)
Other packages that cited wnl R package
View wnl citation profile
Other R packages that wnl depends, imports, suggests or enhances
Complete documentation for wnl
Functions, R codes and Examples using the wnl R package
Some associated functions: BasicUtil . Comp1 . DAT . EnvObj . ExpandDH . Objs . Secondary . SolComp2 . SolComp3 . cmpChi . dx . e . hSkew . nComp . nlr . pComp . pProf . wnl-package . wnl5 . 
Some associated R codes: BasicUtil.R . Comp1.R . EnvObj.R . ExpandDH.R . Objs.R . Secondary.R . SolComp2.R . SolComp3.R . cmpChi.R . dx.R . hSkew.R . nComp.R . nlr.R . pComp.R . pProf.R . wnl5.R .  Full wnl package functions and examples
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