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twoCoprimary  

Sample Size and Power Calculation for Two Co-Primary Endpoints
View on CRAN: Click here


Download and install twoCoprimary package within the R console
Install from CRAN:
install.packages("twoCoprimary")

Install from Github:
library("remotes")
install_github("cran/twoCoprimary")

Install by package version:
library("remotes")
install_version("twoCoprimary", "1.0.0")



Attach the package and use:
library("twoCoprimary")
Maintained by
Gosuke Homma
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2025-11-21
Latest Update: 2025-11-21
Description:
Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.
How to cite:
Gosuke Homma (2025). twoCoprimary: Sample Size and Power Calculation for Two Co-Primary Endpoints. R package version 1.0.0, https://cran.r-project.org/web/packages/twoCoprimary. Accessed 06 Aug. 2026.
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Complete documentation for twoCoprimary
Functions, R codes and Examples using the twoCoprimary R package
Full twoCoprimary package functions and examples
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