Other packages > Find by keyword >

trialr  

Clinical Trial Designs in 'rstan'
View on CRAN: Click here


Download and install trialr package within the R console
Install from CRAN:
install.packages("trialr")

Install from Github:
library("remotes")
install_github("cran/trialr")

Install by package version:
library("remotes")
install_version("trialr", "0.1.6")



Attach the package and use:
library("trialr")
Maintained by
Kristian Brock
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2017-11-21
Latest Update: 2023-03-12
Description:
A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.
How to cite:
Kristian Brock (2017). trialr: Clinical Trial Designs in 'rstan'. R package version 0.1.6, https://cran.r-project.org/web/packages/trialr. Accessed 05 Jun. 2026.
Previous versions and publish date:
0.0.1 (2017-11-21 16:33), 0.0.2 (2018-08-08 22:40), 0.0.3 (2018-08-09 12:20), 0.0.4 (2018-10-24 23:30), 0.0.5 (2018-11-12 17:40), 0.0.6 (2019-01-17 15:10), 0.0.7 (2019-03-03 18:30), 0.1.0 (2019-04-21 23:00), 0.1.1 (2019-05-25 02:00), 0.1.2 (2019-06-25 13:40), 0.1.3 (2020-01-08 23:30), 0.1.4 (2020-04-06 15:20), 0.1.5 (2020-10-16 01:00)
Other packages that cited trialr R package
View trialr citation profile
Other R packages that trialr depends, imports, suggests or enhances
Complete documentation for trialr
Functions, R codes and Examples using the trialr R package
Some associated functions: as.data.frame.crm_fit . as.data.frame.efftox_fit . as.mcmc.list.crm_fit . as.mcmc.list.efftox_fit . as_tibble.augbin_2t_1a_fit . as_tibble.dose_finding_paths . augbin_2t_1a_fit . augbin_fit . binary_prob_success . careful_escalation . closest_to_target . crm_codified_dose_logistic . crm_dtps . crm_fit-class . crm_params-class . crm_path_analysis . crm_prior_beliefs . crm_process . df_parse_outcomes . dose_finding_fit-class . dose_finding_path_node-class . eff_at_dose . efftox_analysis_to_df . efftox_contour_plot . efftox_dtps . efftox_dtps_to_dataframe . efftox_fit-class . efftox_get_tox . efftox_parameters_demo . efftox_params-class . efftox_parse_outcomes . efftox_path_analysis . efftox_priors . efftox_process . efftox_simulate . efftox_solve_p . efftox_superiority . efftox_utility . efftox_utility_density_plot . get_efftox_priors . n_at_dose . parse_dose_finding_outcomes . parse_eff_tox_dose_finding_outcomes . peps2_get_data . peps2_process . plot.crm_fit . plot.efftox_fit . predict.augbin_2t_1a_fit . print.augbin_fit . print.crm_fit . print.efftox_fit . print.nbg_fit . prior_predictive_augbin_2t_1a . prob_success . prob_tox_exceeds . ranBin2 . rlkjcorr . spread_paths . stan_augbin . stan_augbin_demo . stan_crm . stan_efftox . stan_efftox_demo . stan_hierarchical_response_thall . stan_nbg . stan_peps2 . summary.crm_fit . summary.efftox_fit . total_weight_at_dose . tox_at_dose . trialr-package . trialr_simulate . weights_at_dose . 
Some associated R codes: EffTox.R . augbin_2t_1a_fit.R . augbin_fit.R . binary_prob_success.R . careful_escalation.R . crm_codified_dose_logistic.R . crm_dtps.R . crm_fit.R . crm_params.R . crm_path_analysis.R . crm_prior_beliefs.R . crm_process.R . df_parse_outcomes.R . dose_finding_fit.R . dose_finding_path_node.R . dose_finding_paths.R . eff_at_dose.R . efftox_analysis_to_df.R . efftox_contour_plot.R . efftox_dtps.R . efftox_dtps_to_dataframe.R . efftox_fit.R . efftox_get_tox.R . efftox_parameters_demo.R . efftox_params.R . efftox_parse_outcomes.R . efftox_path_analysis.R . efftox_priors.R . efftox_process.R . efftox_simulate.R . efftox_solve_p.R . efftox_superiority.R . efftox_utility.R . efftox_utility_density_plot.R . get_efftox_priors.R . misc.R . n_at_dose.R . nbg_fit.R . parse_dose_finding_outcomes.R . parse_eff_tox_dose_finding_outcomes.R . peps2_get_data.R . peps2_process.R . prior_predictive_augbin_2t_1a.R . prob_success.R . prob_tox_exceeds.R . ranBin2.R . rlkjcorr.R . spread_paths.R . stan_augbin.R . stan_augbin_demo.R . stan_crm.R . stan_efftox.R . stan_efftox_demo.R . stan_hierarchical_response_thall.R . stan_nbg.R . stan_peps2.R . stanmodels.R . total_weight_at_dose.R . tox_at_dose.R . trialr-package.R . trialr_simulate.R . weights_at_dose.R .  Full trialr package functions and examples
Downloads during the last 30 days

Today's Hot Picks in Authors and Packages

envirem  
Generation of ENVIREM Variables
Generation of bioclimatic rasters that are complementary to the typical 19 bioclim variables. ...
Download / Learn more Package Citations See dependency  
quickcode  
Quick and Essential 'R' Tricks for Better Scripts
The NOT functions, 'R' tricks and a compilation of some simple quick plus often used 'R' codes to im ...
Download / Learn more Package Citations See dependency  
ibb  
R Wrapper for Istanbul Municipality Open Data Portal
Call wrappers for Istanbul Metropolitan Municipality's Open Data Portal (Turkish: Istanbul B ...
Download / Learn more Package Citations See dependency  
msm  
Multi-State Markov and Hidden Markov Models in Continuous Time
Functions for fitting continuous-time Markov and hidden Markov multi-state models to longitudinal d ...
Download / Learn more Package Citations See dependency  
crossurr  
Cross-Fitting for Doubly Robust Evaluation of High-Dimensional Surrogate Markers
Doubly robust methods for evaluating surrogate markers as outlined in: Agniel D, Hejblum BP, Thiebau ...
Download / Learn more Package Citations See dependency  

27,268

R Packages

233,548

Dependencies

72,590

Author Associations

27,205

Publication Badges

© Copyright since 2022. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA