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pmxNODE  

Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'
View on CRAN: Click here


Download and install pmxNODE package within the R console
Install from CRAN:
install.packages("pmxNODE")

Install from Github:
library("remotes")
install_github("cran/pmxNODE")

Install by package version:
library("remotes")
install_version("pmxNODE", "0.1.0")



Attach the package and use:
library("pmxNODE")
Maintained by
Dominic Bräm
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2025-11-26
Latest Update: 2025-11-26
Description:
An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.
How to cite:
Dominic Bräm (2025). pmxNODE: Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'. R package version 0.1.0, https://cran.r-project.org/web/packages/pmxNODE. Accessed 26 Jun. 2026.
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