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ordcrm
View on CRAN: Click
here
Download and install ordcrm package within the R console
Install from CRAN:
install.packages("ordcrm")
Install from Github:
library("remotes")
install_github("cran/ordcrm")
Install by package version:
library("remotes")
install_version("ordcrm", "1.0.0")
Attach the package and use:
library("ordcrm")
Maintained by
Emily V. Dressler
[Scholar Profile | Author Map]
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2016-11-04
Latest Update: 2016-11-04
Description:
Provides the setup and calculations needed
to run a likelihood-based continual reassessment method (CRM)
dose finding trial and performs simulations to assess design
performance under various scenarios. 3 dose finding designs
are included in this package: ordinal proportional odds model
(POM) CRM, ordinal continuation ratio (CR) model CRM, and the
binary 2-parameter logistic model CRM.
These functions allow customization of design characteristics
to vary sample size, cohort sizes, target dose-limiting
toxicity (DLT) rates, discrete or continuous dose levels,
combining ordinal grades 0 and 1 into one category, and
incorporate safety and/or stopping rules.
For POM and CR model designs, ordinal toxicity grades are
specified by common terminology criteria for adverse events
(CTCAE) version 4.0.
Function 'pseudodata' creates the necessary starting models
for these 3 designs, and function 'nextdose' estimates the
next dose to test in a cohort of patients for a target DLT
rate.
We also provide the function 'crmsimulations' to assess the
performance of these 3 dose finding designs under various
scenarios.
How to cite:
Emily V. Dressler (2016). ordcrm: Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs. R package version 1.0.0, https://cran.r-project.org/web/packages/ordcrm. Accessed 30 Jan. 2025.
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Complete documentation for ordcrm
Functions, R codes and Examples using
the ordcrm R package
Some associated functions: crmsimulations . nextdose . pseudodata .
Some associated R codes: constraints.R . crmsimulations.R . fiterations.R . nextdose.R . pseudodata.R . Full ordcrm package functions and examples
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