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nlmixr2autoinit  

Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling
View on CRAN: Click here


Download and install nlmixr2autoinit package within the R console
Install from CRAN:
install.packages("nlmixr2autoinit")

Install from Github:
library("remotes")
install_github("cran/nlmixr2autoinit")

Install by package version:
library("remotes")
install_version("nlmixr2autoinit", "1.0.0")



Attach the package and use:
library("nlmixr2autoinit")
Maintained by
Zhonghui Huang
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2025-11-13
Latest Update: 2025-11-13
Description:
Provides automated methods for generating initial parameter estimates in population pharmacokinetic modeling. The pipeline integrates adaptive single-point methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter sweeping across pharmacokinetic models. It estimates residual unexplained variability using either data-driven or fixed-fraction approaches and assigns pragmatic initial values for inter-individual variability. These strategies are designed to improve model robustness and convergence in 'nlmixr2' workflows. For more details see Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025) <doi:10.1007/s10928-025-10000-z>.
How to cite:
Zhonghui Huang (2025). nlmixr2autoinit: Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling. R package version 1.0.0, https://cran.r-project.org/web/packages/nlmixr2autoinit. Accessed 13 Sep. 2026.
Previous versions and publish date:
(2026-07-09 06:25), 1.0.0 (2025-11-13 22:10)
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