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nlmixr2  

Nonlinear Mixed Effects Models in Population PK/PD
View on CRAN: Click here


Download and install nlmixr2 package within the R console
Install from CRAN:
install.packages("nlmixr2")

Install from Github:
library("remotes")
install_github("cran/nlmixr2")

Install by package version:
library("remotes")
install_version("nlmixr2", "5.0.0")



Attach the package and use:
library("nlmixr2")
Maintained by
Matthew Fidler
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2022-05-24
Latest Update: 2025-07-17
Description:
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).
How to cite:
Matthew Fidler (2022). nlmixr2: Nonlinear Mixed Effects Models in Population PK/PD. R package version 5.0.0, https://cran.r-project.org/web/packages/nlmixr2. Accessed 22 Sep. 2026.
Previous versions and publish date:
(2026-08-05 02:20), 2.0.6 (2022-05-24 17:50), 2.0.7 (2022-06-28 00:20), 2.0.8 (2022-10-23 06:02), 2.0.9 (2023-02-21 05:00), 2.1.0 (2024-01-09 11:50), 2.1.1 (2024-02-01 20:20), 2.1.2 (2024-05-30 05:50), 3.0.0 (2024-09-18 21:20), 3.0.1 (2024-10-28 22:30), 3.0.2 (2025-02-20 04:40), 4.0.0 (2025-07-17 06:40), 4.0.1 (2025-08-29 21:30), 5.0.0 (2025-11-30 07:10)
Other packages that cited nlmixr2 R package
View nlmixr2 citation profile
Other R packages that nlmixr2 depends, imports, suggests or enhances
Complete documentation for nlmixr2
Functions, R codes and Examples using the nlmixr2 R package
Some associated functions: addCwres . addNpde . addTable . bootplot . bootstrapFit . covarSearchAuto . foceiControl . nlmeControl . nlmixr2 . nlmixr2CheckInstall . preconditionFit . reexports . saemControl . setOfv . tableControl . traceplot . vpcCens . vpcCensTad . vpcPlot . vpcPlotTad . vpcSim . 
Some associated R codes: hardReexports.R . nlmixr2CheckInstall.R . reexports.R . utils.R .  Full nlmixr2 package functions and examples
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