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microsamplingDesign  

Finding Optimal Microsampling Designs for Non-Compartmental Pharmacokinetic Analysis
View on CRAN: Click here


Download and install microsamplingDesign package within the R console
Install from CRAN:
install.packages("microsamplingDesign")

Install from Github:
library("remotes")
install_github("cran/microsamplingDesign")

Install by package version:
library("remotes")
install_version("microsamplingDesign", "1.0.8")



Attach the package and use:
library("microsamplingDesign")
Maintained by
Adriaan Blommaert
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2018-05-02
Latest Update: 2021-10-13
Description:
Find optimal microsampling designs for non-compartmental pharacokinetic analysis using a general simulation methodology: Algorithm III of Barnett, Helen, Helena Geys, Tom Jacobs, and Thomas Jaki. (2017) "Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies. (currently unpublished)" This methodology consist of (1) specifying a pharmacokinetic model including variability among animals; (2) generating possible sampling times; (3) evaluating performance of each time point choice on simulated data; (4) generating possible schemes given a time point choice and additional constraints and finally (5) evaluating scheme performance on simulated data. The default settings differ from the article of Barnett and others, in the default pharmacokinetic model used and the parameterization of variability among animals. Details can be found in the package vignette. A 'shiny' web application is included, which guides users from model parametrization to optimal microsampling scheme.
How to cite:
Adriaan Blommaert (2018). microsamplingDesign: Finding Optimal Microsampling Designs for Non-Compartmental Pharmacokinetic Analysis. R package version 1.0.8, https://cran.r-project.org/web/packages/microsamplingDesign. Accessed 14 Mar. 2025.
Previous versions and publish date:
1.0.0 (2018-05-02 22:13), 1.0.2 (2018-05-14 15:32), 1.0.5 (2018-08-22 18:30), 1.0.6 (2019-03-20 16:50), 1.0.7 (2020-04-05 21:30), 1.0.8 (2021-10-13 15:52)
Other packages that cited microsamplingDesign R package
View microsamplingDesign citation profile
Other R packages that microsamplingDesign depends, imports, suggests or enhances
Functions, R codes and Examples using the microsamplingDesign R package
Some associated functions: PkData-class . PkModel-class . PkModelParent-class . PkModelRange-class . SetOfSchemes-class . SetOfTimePoints-class . addSchemes . changeDevSettings . checkConstraintsOk . check_scheme_exactNumberObsPerTimePoint . check_scheme_minObsPerTimePoint . check_subject_maxConsecSamples . construct2CompModel . constructSetOfSchemes . doAllSchemeChecks . estimatePopCurve . extractByRank . flagSchemesMeetingConstraints . flattenSetOfSchemes . formatTimePoints . genMVN . get2ComptModelCurve . getAllTimeOptions . getCoeffVariationError . getCombinationsWithMaxNRepetitions . getConstraintsExample . getCorrelationMatrix . getData . getDevRankingSettings . getDosingInfo . getExampleData . getExampleObjective . getExampleParameters . getExamplePkCurve . getExamplePkModel . getExamplePkModelRange . getExampleSetOfSchemes . getExampleSetOfTimePoints . getExampleTimeData . getExampleTimeZones . getIndividualParameters . getMMCurve . getModelFunction . getNSchemes . getNSubjects . getNames . getParameters . getPkData . getPkModel . getPkModelArticle . getPkModels . getRanking . getResultPerScheme . getSetOfSchemes . getSummaryRanks . getTimeChoicePerformance . getTimePoints . getTopNRanking . grapes-ARC-grapes . oneCompartmentOralModel . pkCurveStat . pkOdeModel2Compartments . plotAverageRat . plotMMCurve . plotMMKinetics . plotObject . rankBasedOnDirectory . rankObject . rankObjectWithRange . runMicrosamplingDesignApp . setCoeffVariationError . setCorrelationMatrix . setDosingInfo . setModelToAverageRat . setParameters . setRanking . setTimePoints . subsetOnTimePoints . summary-SetOfSchemes-method . summary . 
Some associated R codes: RcppExports.R . aaaGenerics.R . appFunctions.R . constraintFunctions.R . fastRankSchemes.R . internalHelpers.R . objectPkModel.R . objectPkModelParent.R . objectPkModelRange.R . objectSetOfSchemes.R . objectSetOfTimePoints.R . pkFunctions.R . rankScheme.R . rankTimePoints.R . schemeGenerator.R . schemeStatistics.R . timePointGeneration.R .  Full microsamplingDesign package functions and examples
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