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metasplines  

Pool Literature-Based and Individual Participant Data Based Spline Estimates
View on CRAN: Click here


Download and install metasplines package within the R console
Install from CRAN:
install.packages("metasplines")

Install from Github:
library("remotes")
install_github("cran/metasplines")

Install by package version:
library("remotes")
install_version("metasplines", "0.1.1")



Attach the package and use:
library("metasplines")
Maintained by
Tommi Härkänen
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2025-07-21
Latest Update: 2025-07-21
Description:
Pooling estimates reported in meta-analyses (literature-based, LB) and estimates based on individual participant data (IPD) is not straight-forward as the details of the LB nonlinear function estimate are not usually reported. This package pools the nonlinear IPD dose-response estimates based on a natural cubic spline from lm or glm with the pointwise LB estimates and their estimated variances. Details will be presented in Härkänen, Tapanainen, Sares-Jäske, Männistö, Kaartinen and Paalanen (2025) "Novel pooling method for nonlinear cohort analysis and meta-analysis estimates: Predicting health outcomes based on climate-friendly diets" (under revision) <https://journals.lww.com/epidem/pages/default.aspx>.
How to cite:
Tommi Härkänen (2025). metasplines: Pool Literature-Based and Individual Participant Data Based Spline Estimates. R package version 0.1.1, https://cran.r-project.org/web/packages/metasplines. Accessed 25 Oct. 2026.
Previous versions and publish date:
(2026-07-09 06:29), 0.1.0 (2025-07-21 10:50)
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Complete documentation for metasplines
Functions, R codes and Examples using the metasplines R package
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