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mbbe  

Model Based Bio-Equivalence
View on CRAN: Click here


Download and install mbbe package within the R console
Install from CRAN:
install.packages("mbbe")

Install from Github:
library("remotes")
install_github("cran/mbbe")

Install by package version:
library("remotes")
install_version("mbbe", "0.1.0")



Attach the package and use:
library("mbbe")
Maintained by
Mark Sale
[Scholar Profile | Author Map]
First Published: 2024-02-03
Latest Update: 2024-02-03
Description:
Uses several Nonlinear Mixed effect (NONMEM) models (as NONMEM control files) to perform bootstrap model averaging and Monte Carlo Simulation for Model Based Bio-Equivalence (MBBE). Power is returned as the fraction of the simulations with successful bioequivalence (BE) test, for maximum concentration (Cmax), Area under the curve to the last observed value (AUClast) and Area under the curve extrapolate to infinity (AUCinf). See Hooker, A. (2020) Improved bioequivalence assessment through model-informed and model-based strategies .
How to cite:
Mark Sale (2024). mbbe: Model Based Bio-Equivalence. R package version 0.1.0, https://cran.r-project.org/web/packages/mbbe. Accessed 10 Apr. 2025.
Previous versions and publish date:
No previous versions
Other packages that cited mbbe R package
View mbbe citation profile
Other R packages that mbbe depends, imports, suggests or enhances
Complete documentation for mbbe
Functions, R codes and Examples using the mbbe R package
Some associated functions: calc_NCA . calc_power . run_example . run_mbbe . run_mbbe_json . 
Some associated R codes: MBBE.R . RPenaltyCode.R . get_BEQDF.R . globals.R . run_example.R . utility.R .  Full mbbe package functions and examples
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