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esDesign  

Adaptive Enrichment Designs with Sample Size Re-Estimation
View on CRAN: Click here


Download and install esDesign package within the R console
Install from CRAN:
install.packages("esDesign")

Install from Github:
library("remotes")
install_github("cran/esDesign")

Install by package version:
library("remotes")
install_version("esDesign", "1.0.3")



Attach the package and use:
library("esDesign")
Maintained by
Zhao Yang
[Scholar Profile | Author Map]
First Published: 2018-08-10
Latest Update: 2021-07-13
Description:
Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) . In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) , the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.
How to cite:
Zhao Yang (2018). esDesign: Adaptive Enrichment Designs with Sample Size Re-Estimation. R package version 1.0.3, https://cran.r-project.org/web/packages/esDesign. Accessed 27 Feb. 2025.
Previous versions and publish date:
1.0.0 (2018-08-10 18:30), 1.0.2 (2018-11-23 06:50)
Other packages that cited esDesign R package
View esDesign citation profile
Other R packages that esDesign depends, imports, suggests or enhances
Complete documentation for esDesign
Functions, R codes and Examples using the esDesign R package
Some associated functions: AED.boundary . AED.sim . AED1_SSR.CP . AED1_SSR.N2 . AED1_SSR.boundary . AED1_SSR.sim . AED2_SSR.CP . AED2_SSR.boundary . AED2_SSR.sim . AED3_SSR.CP . AED3_SSR.boundary . AED3_SSR.sim . MaST.sim . SD.sim . SSR.CP . SSR.boundary . SSR.sim . SigP . sSize.norm . 
Some associated R codes: esDesign.R .  Full esDesign package functions and examples
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