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easyLSEA  

Lipid Set Enrichment Analysis with Dual KS and 'fgsea' Engines
View on CRAN: Click here


Download and install easyLSEA package within the R console
Install from CRAN:
install.packages("easyLSEA")

Install from Github:
library("remotes")
install_github("cran/easyLSEA")

Install by package version:
library("remotes")
install_version("easyLSEA", "0.2.1")



Attach the package and use:
library("easyLSEA")
Maintained by
David Guardamino Ojeda
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2026-06-16
Latest Update: 2026-06-16
Description:
Provides biology-aware lipid set enrichment analysis (LSEA) for lipidomics data using dual engines: the Kolmogorov-Smirnov test and the fast gene set enrichment algorithm from the 'fgsea' package. Annotates lipids into biological groups at three levels (lipid class, LIPID MAPS category, functional category) and tests for coordinated directional shifts between conditions. Includes fatty acid chain analysis with trend plots weighted by lipid abundance (Spearman rank correlation, configurable smoothing), wide-format chain position output (sn-1, sn-2, sn-3, sn-4), annotation confidence filtering, and export utilities for reproducible reporting in CSV, 'Excel', and PDF formats. Vignettes are available in English and Spanish. Methods are based on Subramanian et al. (2005) <doi:10.1073/pnas.0506580102> and Korotkevich et al. (2021) <doi:10.1101/060012>.
How to cite:
David Guardamino Ojeda (2026). easyLSEA: Lipid Set Enrichment Analysis with Dual KS and 'fgsea' Engines. R package version 0.2.1, https://cran.r-project.org/web/packages/easyLSEA. Accessed 14 Jul. 2026.
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