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dtpcrm  

Dose Transition Pathways for Continual Reassessment Method
View on CRAN: Click here


Download and install dtpcrm package within the R console
Install from CRAN:
install.packages("dtpcrm")

Install from Github:
library("remotes")
install_github("cran/dtpcrm")

Install by package version:
library("remotes")
install_version("dtpcrm", "0.1.1")



Attach the package and use:
library("dtpcrm")
Maintained by
Christina Yap
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2019-04-10
Latest Update: 2019-08-20
Description:
Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) . DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.
How to cite:
Christina Yap (2019). dtpcrm: Dose Transition Pathways for Continual Reassessment Method. R package version 0.1.1, https://cran.r-project.org/web/packages/dtpcrm. Accessed 02 Nov. 2026.
Previous versions and publish date:
(2026-10-01 17:41), 0.1.0 (2019-04-10 19:56), 0.1.1 (2019-08-20 13:20)
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Complete documentation for dtpcrm
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