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diffdriver  

Identify Differential Selection
View on CRAN: Click here


Download and install diffdriver package within the R console
Install from CRAN:
install.packages("diffdriver")

Install from Github:
library("remotes")
install_github("cran/diffdriver")

Install by package version:
library("remotes")
install_version("diffdriver", "0.1.7")



Attach the package and use:
library("diffdriver")
Maintained by
Siming Zhao
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2026-06-26
Latest Update: 2026-06-26
Description:
Tests for context-dependent selection on cancer driver genes using somatic mutation data. The package implements the DiffDriver statistical framework to assess whether the strength of positive selection on mutations in a driver gene is associated with tumor- or individual-level context variables, such as clinical traits, genomic features, or immune microenvironment subtypes. DiffDriver estimates individual- and position-specific background mutation rates, models selection as a deviation from the background rate using functional annotations, and tests context effects through a latent-variable logistic model. It provides utilities for preparing mutation and annotation data, fitting differential-selection models, running gene-level association tests, summarizing candidate genes, and visualizing mutation patterns. The method is described in Zhou et al. (2026) "Detecting context-dependent selection on cancer driver genes with DiffDriver" <doi:10.64898/2026.04.06.716771>.
How to cite:
Siming Zhao (2026). diffdriver: Identify Differential Selection. R package version 0.1.7, https://cran.r-project.org/web/packages/diffdriver. Accessed 06 Aug. 2026.
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