Other packages > Find by keyword >

dfped  

Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies
View on CRAN: Click here


Download and install dfped package within the R console
Install from CRAN:
install.packages("dfped")

Install from Github:
library("remotes")
install_github("cran/dfped")

Install by package version:
library("remotes")
install_version("dfped", "1.1")



Attach the package and use:
library("dfped")
Maintained by
Artemis Toumazi
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2017-08-01
Latest Update:
Description:
A unified method for designing and analysing dose-finding trials in paediatrics, while bridging information from adults, is proposed in the 'dfped' package. The dose range can be calculated under three extrapolation methods: linear, allometry and maturation adjustment, using pharmacokinetic (PK) data. To do this, it is assumed that target exposures are the same in both populations. The working model and prior distribution parameters of the dose-toxicity and dose-efficacy relationships can be obtained using early phase adult toxicity and efficacy data at several dose levels through 'dfped' package. Priors are used into the dose finding process through a Bayesian model selection or adaptive priors, to facilitate adjusting the amount of prior information to differences between adults and children. This calibrates the model to adjust for misspecification if the adult and paediatric data are very different. User can use his/her own Bayesian model written in Stan code through the 'dfped' package. A template of this model is proposed in the examples of the corresponding R functions in the package. Finally, in this package you can find a simulation function for one trial or for more than one trial. These methods are proposed by Petit et al, (2016) .
How to cite:
Artemis Toumazi (2017). dfped: Extrapolation and Bridging of Adult Information in Early Phase Dose-Finding Paediatrics Studies. R package version 1.1, https://cran.r-project.org/web/packages/dfped. Accessed 07 Mar. 2026.
Previous versions and publish date:
1.0 (2017-08-01 07:06), 1.1 (2018-03-27 23:19)
Other packages that cited dfped R package
View dfped citation profile
Other R packages that dfped depends, imports, suggests or enhances
Complete documentation for dfped
Downloads during the last 30 days

Today's Hot Picks in Authors and Packages

lmSubsets  
Exact Variable-Subset Selection in Linear Regression
Exact and approximation algorithms for variable-subset selection in ordinary linear regression mode ...
Download / Learn more Package Citations See dependency  
ReviewR  
A Light-Weight, Portable Tool for Reviewing Individual Patient Records
A portable Shiny tool to explore patient-level electronic health record data and perform chart revi ...
Download / Learn more Package Citations See dependency  
portalr  
Create Useful Summaries of the Portal Data
Download and generate summaries for the rodent, plant, ant, and weather data from the Portal Projec ...
Download / Learn more Package Citations See dependency  
testDriveR  
Teaching Data for Statistics and Data Science
Provides data sets for teaching statistics and data science courses. It includes a sample of data f ...
Download / Learn more Package Citations See dependency  
nextGenShinyApps  
Craft Exceptional 'R Shiny' Applications and Dashboards with Novel Responsive Tools
Nove responsive tools for designing and developing 'Shiny' dashboards and applications. The scripts ...
Download / Learn more Package Citations See dependency  
SAMtool  
Stock Assessment Methods Toolkit
Simulation tools for closed-loop simulation are provided for the 'MSEtool' operating model to inform ...
Download / Learn more Package Citations See dependency  

26,264

R Packages

223,360

Dependencies

70,376

Author Associations

26,265

Publication Badges

© Copyright since 2022. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA