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crm12Comb  

Phase I/II CRM Based Drug Combination Design
View on CRAN: Click here


Download and install crm12Comb package within the R console
Install from CRAN:
install.packages("crm12Comb")

Install from Github:
library("remotes")
install_github("cran/crm12Comb")

Install by package version:
library("remotes")
install_version("crm12Comb", "0.1.9")



Attach the package and use:
library("crm12Comb")
Maintained by
Junying Wang
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2024-05-02
Latest Update: 2024-05-02
Description:
Implements the adaptive designs for integrated phase I/II trials of drug combinations via continual reassessment method (CRM) to evaluate toxicity and efficacy simultaneously for each enrolled patient cohort based on Bayesian inference. It supports patients assignment guidance in a single trial using current enrolled data, as well as conducting extensive simulation studies to evaluate operating characteristics before the trial starts. It includes various link functions such as empiric, one-parameter logistic, two-parameter logistic, and hyperbolic tangent, as well as considering multiple prior distributions of the parameters like normal distribution, gamma distribution and exponential distribution to accommodate diverse clinical scenarios. Method using Bayesian framework with empiric link function is described in: Wages and Conaway (2014) <doi:10.1002/sim.6097>.
How to cite:
Junying Wang (2024). crm12Comb: Phase I/II CRM Based Drug Combination Design. R package version 0.1.9, https://cran.r-project.org/web/packages/crm12Comb. Accessed 23 Dec. 2024.
Previous versions and publish date:
0.1.3 (2024-05-02 17:52), 0.1.4 (2024-05-27 00:30), 0.1.5 (2024-06-04 23:00), 0.1.6 (2024-06-07 14:20), 0.1.7 (2024-09-16 16:30), 0.1.8 (2024-11-03 17:50)
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