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UnifiedDoseFinding  

Dose-Finding Methods for Non-Binary Outcomes
View on CRAN: Click here


Download and install UnifiedDoseFinding package within the R console
Install from CRAN:
install.packages("UnifiedDoseFinding")

Install from Github:
library("remotes")
install_github("cran/UnifiedDoseFinding")

Install by package version:
library("remotes")
install_version("UnifiedDoseFinding", "0.1.10")



Attach the package and use:
library("UnifiedDoseFinding")
Maintained by
Chia-Wei Hsu
[Scholar Profile | Author Map]
First Published: 2020-07-08
Latest Update: 2022-10-15
Description:
In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess design’s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) <doi:10.1111/j.1541-0420.2008.01045.x>), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) <doi:10.1111/j.1541-0420.2006.00666.x>, Pan et al. (2014) <doi:10.1371/journal.pone.0098147>) and generalized BOIN design (Mu et al. (2018) <doi:10.1111/rssc.12263>). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules.
How to cite:
Chia-Wei Hsu (2020). UnifiedDoseFinding: Dose-Finding Methods for Non-Binary Outcomes. R package version 0.1.10, https://cran.r-project.org/web/packages/UnifiedDoseFinding. Accessed 29 Mar. 2025.
Previous versions and publish date:
0.1.7 (2020-07-08 10:30), 0.1.8 (2021-06-04 18:40), 0.1.9 (2022-02-03 23:10)
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Complete documentation for UnifiedDoseFinding
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