Other packages > Find by keyword >

TITEgBOIN  

Time-to-Event Dose-Finding Design for Multiple Toxicity Grades
View on CRAN: Click here


Download and install TITEgBOIN package within the R console
Install from CRAN:
install.packages("TITEgBOIN")

Install from Github:
library("remotes")
install_github("cran/TITEgBOIN")

Install by package version:
library("remotes")
install_version("TITEgBOIN", "0.4.0")



Attach the package and use:
library("TITEgBOIN")
Maintained by
Jing Zhu
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2023-07-17
Latest Update: 2025-02-26
Description:
In some phase I trials, the design goal is to find the dose associated with a certain target toxicity rate or the dose with a certain weighted sum of rates of various toxicity grades. 'TITEgBOIN' provides the set up and calculations needed to run a dose-finding trial using bayesian optimal interval (BOIN) (Yuan et al. (2016) <doi:10.1158/1078-0432.CCR-16-0592>), generalized bayesian optimal interval (gBOIN) (Mu et al. (2019) <doi:10.1111/rssc.12263>), time-to-event bayesian optimal interval (TITEBOIN) (Lin et al. (2020) <doi:10.1093/biostatistics/kxz007>) and time-to-event generalized bayesian optimal interval (TITEgBOIN) (Takeda et al. (2022) <doi:10.1002/pst.2182>) designs. 'TITEgBOIN' can conduct tasks: run simulations and get operating characteristics; determine the dose for the next cohort; select maximum tolerated dose (MTD). These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose limiting toxicity (DLT) rates or target normalized equivalent toxicity score (ETS) rates to account for discrete toxicity score, and incorporate safety and/or stopping rules.
How to cite:
Jing Zhu (2023). TITEgBOIN: Time-to-Event Dose-Finding Design for Multiple Toxicity Grades. R package version 0.4.0, https://cran.r-project.org/web/packages/TITEgBOIN. Accessed 24 Oct. 2026.
Previous versions and publish date:
(2026-07-09 08:27), 0.3.0 (2023-12-01 14:30)
Other packages that cited TITEgBOIN R package
View TITEgBOIN citation profile
Other R packages that TITEgBOIN depends, imports, suggests or enhances
Complete documentation for TITEgBOIN
Functions, R codes and Examples using the TITEgBOIN R package
Full TITEgBOIN package functions and examples
Downloads during the last 30 days

Today's Hot Picks in Authors and Packages

magicfor  
Magic Functions to Obtain Results from for Loops
Magic functions to obtain results from for loops. ...
Download / Learn more Package Citations See dependency  
forecastHybrid  
Convenient Functions for Ensemble Time Series Forecasts
Convenient functions for ensemble forecasts in R combining approaches from the 'forecast' package. ...
Download / Learn more Package Citations See dependency  
givitiR  
The GiViTI Calibration Test and Belt
Functions to assess the calibration of logistic regression models with the GiViTI (Gruppo Italiano p ...
Download / Learn more Package Citations See dependency  
climwin  
Climate Window Analysis
Contains functions to detect and visualise periods of climate sensitivity (climate windows) for a g ...
Download / Learn more Package Citations See dependency  
FDRsampsize  
Compute Sample Size that Meets Requirements for Average Power and FDR
Defines a collection of functions to compute average power and sample size for studies that use the ...
Download / Learn more Package Citations See dependency  
gemlog  
File Conversion for "Gem Infrasound Logger"
Reads data files from the 'Gem infrasound logger' for analysis and converts to segy format (which is ...
Download / Learn more Package Citations See dependency  

29,080

R Packages

247,686

Dependencies

77,281

Author Associations

29,081

Publication Badges

© Copyright since 2022. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA