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SurrogateRegression  

Surrogate Outcome Regression Analysis
View on CRAN: Click here


Download and install SurrogateRegression package within the R console
Install from CRAN:
install.packages("SurrogateRegression")

Install from Github:
library("remotes")
install_github("cran/SurrogateRegression")

Install by package version:
library("remotes")
install_version("SurrogateRegression", "0.6.0.1")



Attach the package and use:
library("SurrogateRegression")
Maintained by
Zachary McCaw
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2020-12-03
Latest Update: 2022-08-05
Description:
Performs estimation and inference on a partially missing target outcome (e.g. gene expression in an inaccessible tissue) while borrowing information from a correlated surrogate outcome (e.g. gene expression in an accessible tissue). Rather than regarding the surrogate outcome as a proxy for the target outcome, this package jointly models the target and surrogate outcomes within a bivariate regression framework. Unobserved values of either outcome are treated as missing data. In contrast to imputation-based inference, no assumptions are required regarding the relationship between the target and surrogate outcomes. Estimation in the presence of bilateral outcome missingness is performed via an expectation conditional maximization either algorithm. In the case of unilateral target missingness, estimation is performed using an accelerated least squares procedure. A flexible association test is provided for evaluating hypotheses about the target regression parameters. For additional details, see: McCaw ZR, Gaynor SM, Sun R, Lin X: "Leveraging a surrogate outcome to improve inference on a partially missing target outcome" <doi:10.1111/biom.13629>.
How to cite:
Zachary McCaw (2020). SurrogateRegression: Surrogate Outcome Regression Analysis. R package version 0.6.0.1, https://cran.r-project.org/web/packages/SurrogateRegression. Accessed 07 Nov. 2024.
Previous versions and publish date:
0.5.0 (2020-12-03 11:10), 0.6.0 (2022-08-05 22:40)
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