Other packages > Find by keyword >

SimTOST  

Sample Size Estimation for Bio-Equivalence Trials Through Simulation
View on CRAN: Click here


Download and install SimTOST package within the R console
Install from CRAN:
install.packages("SimTOST")

Install from Github:
library("remotes")
install_github("cran/SimTOST")

Install by package version:
library("remotes")
install_version("SimTOST", "1.0.2")



Attach the package and use:
library("SimTOST")
Maintained by
Thomas Debray
[Scholar Profile | Author Map]
First Published: 2025-02-18
Latest Update: 2025-02-18
Description:
Sample size estimation for bio-equivalence trials is supported through a simulation-based approach that extends the Two One-Sided Tests (TOST) procedure. The methodology provides flexibility in hypothesis testing, accommodates multiple treatment comparisons, and accounts for correlated endpoints. Users can model complex trial scenarios, including parallel and crossover designs, intra-subject variability, and different equivalence margins. Monte Carlo simulations enable accurate estimation of power and type I error rates, ensuring well-calibrated study designs. The statistical framework builds on established methods for equivalence testing and multiple hypothesis testing in bio-equivalence studies, as described in Schuirmann (1987) <doi:10.1007/BF01068419>, Mielke et al. (2018) <doi:10.1080/19466315.2017.1371071>, Shieh (2022) <doi:10.1371/journal.pone.0269128>, and Sozu et al. (2015) <doi:10.1007/978-3-319-22005-5>. Comprehensive documentation and vignettes guide users through implementation and interpretation of results.
How to cite:
Thomas Debray (2025). SimTOST: Sample Size Estimation for Bio-Equivalence Trials Through Simulation. R package version 1.0.2, https://cran.r-project.org/web/packages/SimTOST. Accessed 01 Apr. 2025.
Previous versions and publish date:
1.0.1 (2025-02-18 11:10)
Other packages that cited SimTOST R package
View SimTOST citation profile
Other R packages that SimTOST depends, imports, suggests or enhances
Complete documentation for SimTOST
Functions, R codes and Examples using the SimTOST R package
Full SimTOST package functions and examples
Downloads during the last 30 days
03/0203/0303/0403/0503/0603/0703/0803/0903/1003/1103/1203/1303/1403/1503/1603/1703/1803/1903/2003/2103/2203/2303/2403/2503/2603/2703/2803/2903/3003/31Downloads for SimTOST24681012141618TrendBars

Today's Hot Picks in Authors and Packages

eSIR  
Extended State-Space SIR Models
An implementation of extended state-space SIR models developed by Song Lab at UM school of Public H ...
Download / Learn more Package Citations See dependency  
shinyBS  
Twitter Bootstrap Components for Shiny
Adds additional Twitter Bootstrap components to Shiny. ...
Download / Learn more Package Citations See dependency  
simplevis  
Wrappers to Simplify Beautiful "ggplot2" and "leaflet" Visualisation
Wrapper functions around the amazing 'leaflet' package that aims to simplify 'leaflet' visualisatio ...
Download / Learn more Package Citations See dependency  
quickcode  
Quick and Essential 'R' Tricks for Better Scripts
The NOT functions, 'R' tricks and a compilation of some simple quick plus often used 'R' codes to im ...
Download / Learn more Package Citations See dependency  
samplesize  
Sample Size Calculation for Various t-Tests and Wilcoxon-Test
Computes sample size for Student's t-test and for the Wilcoxon-Mann-Whitney test for categorical dat ...
Download / Learn more Package Citations See dependency  
gasmodel  
Generalized Autoregressive Score Models
Estimation, forecasting, and simulation of generalized autoregressive score (GAS) models of Creal, ...
Download / Learn more Package Citations See dependency  

23,842

R Packages

207,311

Dependencies

64,420

Author Associations

23,781

Publication Badges

© Copyright since 2022. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA