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PKPDsim  

Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations
View on CRAN: Click here


Download and install PKPDsim package within the R console
Install from CRAN:
install.packages("PKPDsim")

Install from Github:
library("remotes")
install_github("cran/PKPDsim")

Install by package version:
library("remotes")
install_version("PKPDsim", "1.4.1")



Attach the package and use:
library("PKPDsim")
Maintained by
Ron Keizer
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2022-01-19
Latest Update: 2025-04-17
Description:
Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) ).
How to cite:
Ron Keizer (2022). PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations. R package version 1.4.1, https://cran.r-project.org/web/packages/PKPDsim. Accessed 29 Aug. 2026.
Previous versions and publish date:
(2026-07-09 08:16), 1.1.0 (2022-01-19 09:22), 1.1.1 (2022-04-01 10:10), 1.3.0 (2023-03-02 13:20), 1.4.0 (2024-08-20 01:20)
Other packages that cited PKPDsim R package
View PKPDsim citation profile
Other R packages that PKPDsim depends, imports, suggests or enhances
Complete documentation for PKPDsim
Functions, R codes and Examples using the PKPDsim R package
Some associated functions: OneCompIVbolus . OneCompIVinfusion . OneCompOral . PKPDsim-package . ThreeCompIVbolus . ThreeCompIVinfusion . ThreeCompIVinfusionMetab . ThreeCompOral . ThreeCompOralMetab . TwoCompIVbolus . TwoCompIVinfusion . TwoCompOral . add_quotes . add_ruv . add_ruv_to_quantile . adherence_binomial . adherence_markov . advan . advan_create_data . advan_parse_output . advan_process_infusion_doses . analytical_eqn_wrapper . apply_lagtime . bioavailability_to_R_code . calc_dydP . calc_ss_analytic . calculate_parameters . check_iov_specification . check_mixture_model . compile_sim_cpp . covariate_last_obs_only . covariates_table_to_list . create_event_table . create_obs_data . cv_to_omega . define_tdm_init_model . detect_ode_syntax . f_cov . get_ode_model_size . get_parameters_from_code . get_t_obs_from_regimen . get_var_y . ifelse0 . is_newer_package . is_positive_definite . join_cov_and_par . join_regimen . merge_regimen . model_from_api . model_library . mvrnorm2 . na_locf . new_adherence . new_covariate . new_covariate_model . new_ode_model . new_regimen . nlmixr_parse_parameters . nm_to_regimen . now_utc . parse_obs_types . pkdata . pkpdsim_to_nlmixr . pop_regimen . print.PKPDsim . print.covariate . print.regimen . print_list . read_model_json . regimen_to_nm . reparametrize . search_replace_in_file . shift_regimen . shift_state_indices . sim . sim_core . sim_ode . sim_ode_shiny . table_to_list . test_model . test_pointer . translate_ode . triangle_to_full . vector_to_R_code . 
Some associated R codes: PKPDsim-package.R . RcppExports.R . add_ruv.R . add_ruv_to_quantile.R . adherence.R . advan.R . advan_create_data.R . advan_parse_output.R . advan_process_infusion_doses.R . analytical_eqn_wrapper.R . apply_lagtime.R . calc_ss_analytic.R . calculate_parameters.R . check_iov_specification.R . check_mixture_model.R . compile_sim_cpp.R . covariate_last_obs_only.R . covariates_table_to_list.R . create_event_table.R . create_obs_data.R . cv_to_omega.R . define_tdm_init_model.R . detect_ode_syntax.R . get_ode_model_size.R . get_parameters_from_code.R . get_t_obs_from_regimen.R . get_var_y.R . ifelse0.R . is_newer_package.R . is_positive_definite.R . join_cov_and_par.R . join_regimen.R . merge_regimen.R . misc.R . model_from_api.R . model_library.R . mvrnorm2.R . na_locf.R . new_covariate.R . new_covariate_model.R . new_ode_model.R . new_regimen.R . nlmixr_parse_parameters.R . nm_to_regimen.R . object_to_R_code.R . parse_obs_types.R . pkdata.R . pkpdsim_to_nlmixr.R . pop_regimen.R . print.PKPDsim.R . print.covariate.R . print.regimen.R . read_model_json.R . regimen_to_nm.R . reparametrize.R . shift_regimen.R . shift_state_indices.R . sim.R . sim_core.R . sim_ode.R . sim_ode_shiny.R . table_to_list.R . test_model.R . test_pointer.R . translate_ode.R . triangle_to_full.R . zzz.R .  Full PKPDsim package functions and examples
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