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HybridDesign  

Hybrid Design for Phase I Dose-Finding Studies
View on CRAN: Click here


Download and install HybridDesign package within the R console
Install from CRAN:
install.packages("HybridDesign")

Install from Github:
library("remotes")
install_github("cran/HybridDesign")

Install by package version:
library("remotes")
install_version("HybridDesign", "1.0")



Attach the package and use:
library("HybridDesign")
Maintained by
Heng Zhou
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2022-12-15
Latest Update: 2022-12-15
Description:
The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 .
How to cite:
Heng Zhou (2022). HybridDesign: Hybrid Design for Phase I Dose-Finding Studies. R package version 1.0, https://cran.r-project.org/web/packages/HybridDesign. Accessed 06 Jun. 2026.
Previous versions and publish date:
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View HybridDesign citation profile
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Complete documentation for HybridDesign
Functions, R codes and Examples using the HybridDesign R package
Some associated functions: get_boundary_mtpi . get_oc_hybrid . hybrid . hybrid_MTD_selection . 
Some associated R codes: get_boundary_mtpi.R . get_oc_hybrid.R . hybrid.R . hybrid_MTD_selection.R .  Full HybridDesign package functions and examples
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