Other packages > Find by keyword >

HDMT  

A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses
View on CRAN: Click here


Download and install HDMT package within the R console
Install from CRAN:
install.packages("HDMT")

Install from Github:
library("remotes")
install_github("cran/HDMT")

Install by package version:
library("remotes")
install_version("HDMT", "1.0.5")



Attach the package and use:
library("HDMT")
Maintained by
James Dai
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2019-04-16
Latest Update: 2022-01-29
Description:
A multiple-testing procedure for high-dimensional mediation hypotheses. Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods for mediation analyses, the popular joint significance (JS) test yields an overly conservative type I error rate and therefore low power. In the R package 'HDMT' we implement a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when using JS for testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of three component null hypotheses and deriving the corresponding mixture distribution of null p-values. Results of the data examples include better-behaved quantile-quantile plots and improved detection of novel mediation relationships on the role of DNA methylation in genetic regulation of gene expression. With increasing interest in mediation by molecular intermediaries such as gene expression, the proposed method addresses an unmet methodological challenge. Methods used in the package refer to James Y. Dai, Janet L. Stanford & Michael LeBlanc (2020) .
How to cite:
James Dai (2019). HDMT: A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses. R package version 1.0.5, https://cran.r-project.org/web/packages/HDMT. Accessed 21 Nov. 2024.
Previous versions and publish date:
1.0.1 (2019-12-05 06:50), 1.0.2 (2020-10-07 06:30), 1.0.3 (2021-02-20 23:30), 1.0.4 (2021-12-06 23:20), 1.0 (2019-04-16 14:42)
Other packages that cited HDMT R package
View HDMT citation profile
Other R packages that HDMT depends, imports, suggests or enhances
Complete documentation for HDMT
Functions, R codes and Examples using the HDMT R package
Some associated functions: adjust_quantile . correct_qqplot . exercise_input . fdr_est . fwer_est . null_estimation . snp_input . 
Some associated R codes: adjust_quantile.R . correct_qqplot.R . fdr_est.R . fwer_est.R . null_estimation.R .  Full HDMT package functions and examples
Downloads during the last 30 days
Get rewarded with contribution points by helping add
Reviews / comments / questions /suggestions ↴↴↴

Today's Hot Picks in Authors and Packages

pkgdepends  
Package Dependency Resolution and Downloads
Find recursive dependencies of 'R' packages from various sources. Solve the dependencies to obtain ...
Download / Learn more Package Citations See dependency  
deductive  
Data Correction and Imputation Using Deductive Methods
Attempt to repair inconsistencies and missing values in data records by using information from vali ...
Download / Learn more Package Citations See dependency  
SCBiclust  
Identifies Mean, Variance, and Hierarchically Clustered Biclusters
Identifies a bicluster, a submatrix of the data such that the features and observations within the s ...
Download / Learn more Package Citations See dependency  
crossrun  
Joint Distribution of Number of Crossings and Longest Run
Joint distribution of number of crossings and the longest run in a series of independent Bernoulli ...
Download / Learn more Package Citations See dependency  
RcppHNSW  
'Rcpp' Bindings for 'hnswlib', a Library for Approximate Nearest Neighbors
'Hnswlib' is a C++ library for Approximate Nearest Neighbors. This package provides a minimal R int ...
Download / Learn more Package Citations See dependency  
r2resize  
In-Text Resize for Images, Tables and Fancy Resize Containers in 'shiny', 'rmarkdown' and 'quarto' Documents
Automatic resizing toolbar for containers, images and tables. Various resizable or expandable contai ...
Download / Learn more Package Citations See dependency  

23,229

R Packages

199,929

Dependencies

62,984

Author Associations

23,230

Publication Badges

© Copyright 2022 - present. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA