Other packages > Find by keyword >

HDMT  

A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses
View on CRAN: Click here


Download and install HDMT package within the R console
Install from CRAN:
install.packages("HDMT")

Install from Github:
library("remotes")
install_github("cran/HDMT")

Install by package version:
library("remotes")
install_version("HDMT", "1.0.5")



Attach the package and use:
library("HDMT")
Maintained by
James Dai
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2019-04-16
Latest Update: 2022-01-29
Description:
A multiple-testing procedure for high-dimensional mediation hypotheses. Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods for mediation analyses, the popular joint significance (JS) test yields an overly conservative type I error rate and therefore low power. In the R package 'HDMT' we implement a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when using JS for testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of three component null hypotheses and deriving the corresponding mixture distribution of null p-values. Results of the data examples include better-behaved quantile-quantile plots and improved detection of novel mediation relationships on the role of DNA methylation in genetic regulation of gene expression. With increasing interest in mediation by molecular intermediaries such as gene expression, the proposed method addresses an unmet methodological challenge. Methods used in the package refer to James Y. Dai, Janet L. Stanford & Michael LeBlanc (2020) .
How to cite:
James Dai (2019). HDMT: A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses. R package version 1.0.5, https://cran.r-project.org/web/packages/HDMT. Accessed 15 Jul. 2026.
Previous versions and publish date:
1.0.1 (2019-12-05 06:50), 1.0.2 (2020-10-07 06:30), 1.0.3 (2021-02-20 23:30), 1.0.4 (2021-12-06 23:20), 1.0 (2019-04-16 14:42), (2026-07-09 08:06)
Other packages that cited HDMT R package
View HDMT citation profile
Other R packages that HDMT depends, imports, suggests or enhances
Complete documentation for HDMT
Functions, R codes and Examples using the HDMT R package
Some associated functions: adjust_quantile . correct_qqplot . exercise_input . fdr_est . fwer_est . null_estimation . snp_input . 
Some associated R codes: adjust_quantile.R . correct_qqplot.R . fdr_est.R . fwer_est.R . null_estimation.R .  Full HDMT package functions and examples
Downloads during the last 30 days

Today's Hot Picks in Authors and Packages

PermAlgo  
Permutational Algorithm to Simulate Survival Data
This version of the permutational algorithm generates a dataset in which event and censoring times ...
Download / Learn more Package Citations See dependency  
footBayes  
Fitting Bayesian and MLE Football Models
This is the first package allowing for the estimation, visualization and prediction of the most wel ...
Download / Learn more Package Citations See dependency  
r2resize  
In-Text Resize for Images, Tables and Fancy Resize Containers in 'shiny', 'rmarkdown' and 'quarto' Documents
Automatic resizing toolbar for containers, images and tables. Various resizable or expandable contai ...
Download / Learn more Package Citations See dependency  
gscaLCA  
Generalized Structure Component Analysis- Latent Class Analysis & Latent Class Regression
Execute Latent Class Analysis (LCA) and Latent Class Regression (LCR) by using Generalized Structu ...
Download / Learn more Package Citations See dependency  
gamlss.add  
Extra Additive Terms for Generalized Additive Models for Location Scale and Shape
Interface for extra smooth functions including tensor products, neural networks and decision trees. ...
Download / Learn more Package Citations See dependency  
pulseTD  
Identification of Transcriptional Dynamics using Pulse Models via 4su-Seq Data and RNA-Seq Data
A tool for analyzing the transcription, processing and degradation rates of genes by 4sU-seq (the Me ...
Download / Learn more Package Citations See dependency  

27,806

R Packages

239,283

Dependencies

73,837

Author Associations

27,807

Publication Badges

© Copyright since 2022. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA