Other packages > Find by keyword >

HDMT  

A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses
View on CRAN: Click here


Download and install HDMT package within the R console
Install from CRAN:
install.packages("HDMT")

Install from Github:
library("remotes")
install_github("cran/HDMT")

Install by package version:
library("remotes")
install_version("HDMT", "1.0.5")



Attach the package and use:
library("HDMT")
Maintained by
James Dai
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2019-04-16
Latest Update: 2022-01-29
Description:
A multiple-testing procedure for high-dimensional mediation hypotheses. Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods for mediation analyses, the popular joint significance (JS) test yields an overly conservative type I error rate and therefore low power. In the R package 'HDMT' we implement a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when using JS for testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of three component null hypotheses and deriving the corresponding mixture distribution of null p-values. Results of the data examples include better-behaved quantile-quantile plots and improved detection of novel mediation relationships on the role of DNA methylation in genetic regulation of gene expression. With increasing interest in mediation by molecular intermediaries such as gene expression, the proposed method addresses an unmet methodological challenge. Methods used in the package refer to James Y. Dai, Janet L. Stanford & Michael LeBlanc (2020) .
How to cite:
James Dai (2019). HDMT: A Multiple Testing Procedure for High-Dimensional Mediation Hypotheses. R package version 1.0.5, https://cran.r-project.org/web/packages/HDMT. Accessed 27 Oct. 2026.
Previous versions and publish date:
1.0.1 (2019-12-05 06:50), 1.0.2 (2020-10-07 06:30), 1.0.3 (2021-02-20 23:30), 1.0.4 (2021-12-06 23:20), 1.0 (2019-04-16 14:42), (2026-07-09 08:06)
Other packages that cited HDMT R package
View HDMT citation profile
Other R packages that HDMT depends, imports, suggests or enhances
Complete documentation for HDMT
Functions, R codes and Examples using the HDMT R package
Some associated functions: adjust_quantile . correct_qqplot . exercise_input . fdr_est . fwer_est . null_estimation . snp_input . 
Some associated R codes: adjust_quantile.R . correct_qqplot.R . fdr_est.R . fwer_est.R . null_estimation.R .  Full HDMT package functions and examples
Downloads during the last 30 days

Today's Hot Picks in Authors and Packages

r2resize  
In-Text Resize for Images, Tables and Fancy Resize Containers in 'shiny', 'rmarkdown' and 'quarto' Documents
Automatic resizing toolbar for containers, images and tables. Various resizable or expandable contai ...
Download / Learn more Package Citations See dependency  
SGB  
Simplicial Generalized Beta Regression
Main properties and regression procedures using a generalization of the Dirichlet distribution calle ...
Download / Learn more Package Citations See dependency  
spanish  
Translate Quantities from Strings to Integer and Back. Misc Functions on Spanish Data
Character vector to numerical translation in Euros from Spanish spelled monetary quantities. Reverse ...
Download / Learn more Package Citations See dependency  
usemodels  
Boilerplate Code for 'Tidymodels' Analyses
Code snippets to fit models using the tidymodels framework can be easily created for a given data se ...
Download / Learn more Package Citations See dependency  
exams2learnr  
Interface for 'exams' Exercises in 'learnr' Tutorials
Automatic generation of quizzes or individual questions for 'learnr' tutorials based on 'R/exams' ex ...
Download / Learn more Package Citations See dependency  

29,218

R Packages

247,686

Dependencies

77,281

Author Associations

29,219

Publication Badges

© Copyright since 2022. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA