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DTEBOP2  

Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes
View on CRAN: Click here


Download and install DTEBOP2 package within the R console
Install from CRAN:
install.packages("DTEBOP2")

Install from Github:
library("remotes")
install_github("cran/DTEBOP2")

Install by package version:
library("remotes")
install_version("DTEBOP2", "1.0.3")



Attach the package and use:
library("DTEBOP2")
Maintained by
Zhongheng Cai
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2025-05-09
Latest Update: 2025-05-09
Description:
Implements a Bayesian Optimal Phase II design (DTE-BOP2) for trials with delayed treatment effects, particularly relevant to immunotherapy studies where treatment benefits may emerge after a delay. The method builds upon the BOP2 framework and incorporates uncertainty in the delay timepoint through a truncated gamma prior, informed by expert knowledge or default settings. Supports two-arm trial designs with functionality for sample size determination, interim and final analyses, and comprehensive simulation under various delay and design scenarios. Ensures rigorous type I and II error control while improving trial efficiency and power when the delay effect is present. A manuscript describing the methodology is under development and will be formally referenced upon publication.
How to cite:
Zhongheng Cai (2025). DTEBOP2: Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed Outcomes. R package version 1.0.3, https://cran.r-project.org/web/packages/DTEBOP2. Accessed 24 Oct. 2026.
Previous versions and publish date:
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Complete documentation for DTEBOP2
Functions, R codes and Examples using the DTEBOP2 R package
Full DTEBOP2 package functions and examples
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