Other packages > Find by keyword >

BOIN  

Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials
View on CRAN: Click here


Download and install BOIN package within the R console
Install from CRAN:
install.packages("BOIN")

Install from Github:
library("remotes")
install_github("cran/BOIN")

Install by package version:
library("remotes")
install_version("BOIN", "2.7.2")



Attach the package and use:
library("BOIN")
Maintained by
Ying Yuan
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2014-09-19
Latest Update: 2021-01-19
Description:
The Bayesian optimal interval (BOIN) design is a novel phase I clinical trial design for finding the maximum tolerated dose (MTD). It can be used to design both single-agent and drug-combination trials. The BOIN design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. The prominent advantage of the BOIN design is that it achieves simplicity and superior performance at the same time. The BOIN design is algorithm-based and can be implemented in a simple way similar to the traditional 3+3 design. The BOIN design yields an average performance that is comparable to that of the continual reassessment method (CRM, one of the best model-based designs) in terms of selecting the MTD, but has a substantially lower risk of assigning patients to subtherapeutic or overly toxic doses. For tutorial, please check Yan et al. (2020) .
How to cite:
Ying Yuan (2014). BOIN: Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials. R package version 2.7.2, https://cran.r-project.org/web/packages/BOIN. Accessed 03 Dec. 2024.
Previous versions and publish date:
1.0 (2014-09-19 17:28), 1.1 (2015-02-15 07:35), 1.2 (2015-07-28 00:19), 2.0 (2015-09-04 21:49), 2.1 (2016-03-02 01:44), 2.2 (2016-04-22 08:40), 2.3 (2016-05-29 21:29), 2.4 (2016-08-09 01:37), 2.6.1 (2018-03-16 19:04), 2.6.2 (2018-03-27 09:24), 2.6.3 (2018-04-10 17:39), 2.6.4 (2018-10-12 23:50), 2.6.5 (2020-05-20 19:20), 2.6.6 (2020-05-23 08:50), 2.6.7 (2020-06-06 19:30), 2.6.8 (2020-06-30 07:00), 2.6.9 (2020-09-01 11:50), 2.6 (2018-02-21 19:09), 2.7.0 (2020-09-29 10:30), 2.7.1 (2020-11-19 23:20)
Other packages that cited BOIN R package
View BOIN citation profile
Other R packages that BOIN depends, imports, suggests or enhances
Complete documentation for BOIN
Functions, R codes and Examples using the BOIN R package
Some associated functions: get.boundary . get.oc.comb . get.oc . next.comb . next.subtrial . plot.boin . print.boin . select.mtd.comb . select.mtd . summary.boin . 
Some associated R codes: get.boundary.R . get.oc.R . get.oc.comb.R . next.comb.R . next.subtrial.R . plot.boin.R . print.boin.R . select.mtd.R . select.mtd.comb.R . summary.boin.R .  Full BOIN package functions and examples
Downloads during the last 30 days
Get rewarded with contribution points by helping add
Reviews / comments / questions /suggestions ↴↴↴

Today's Hot Picks in Authors and Packages

donut  
Nearest Neighbour Search with Variables on a Torus
Finds the k nearest neighbours in a dataset of specified points, adding the option to wrap certain ...
Download / Learn more Package Citations See dependency  
telemac  
R Interface to the TELEMAC Model Suite
An R interface to the TELEMAC suite for modelling of free surface flow. This includes methods for m ...
Download / Learn more Package Citations See dependency  
r2resize  
In-Text Resize for Images, Tables and Fancy Resize Containers in 'shiny', 'rmarkdown' and 'quarto' Documents
Automatic resizing toolbar for containers, images and tables. Various resizable or expandable contai ...
Download / Learn more Package Citations See dependency  
EDOtrans  
Euclidean Distance-Optimized Data Transformation
A data transformation method which takes into account the special property of scale non-invariance w ...
Download / Learn more Package Citations See dependency  
FSInteract  
Fast Searches for Interactions
Performs fast detection of interactions in large-scale data using the method of random intersection ...
Download / Learn more Package Citations See dependency  
CRANsearcher  
RStudio Addin for Searching Packages in CRAN Database Based on Keywords
One of the strengths of R is its vast package ecosystem. Indeed, R packages extend from visualizatio ...
Download / Learn more Package Citations See dependency  

23,310

R Packages

200,798

Dependencies

63,203

Author Associations

23,278

Publication Badges

© Copyright 2022 - present. All right reserved, rpkg.net.  Based in Cambridge, Massachusetts, USA