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BOIN
View on CRAN: Click
here
Download and install BOIN package within the R console
Install from CRAN:
install.packages("BOIN")
Install from Github:
library("remotes")
install_github("cran/BOIN")
Install by package version:
library("remotes")
install_version("BOIN", "2.7.2")
Attach the package and use:
library("BOIN")
Maintained by
Ying Yuan
[Scholar Profile | Author Map]
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2014-09-19
Latest Update: 2021-01-19
Description:
The Bayesian optimal interval (BOIN) design is a novel phase I
clinical trial design for finding the maximum tolerated dose (MTD). It can be
used to design both single-agent and drug-combination trials. The BOIN design
is motivated by the top priority and concern of clinicians when testing a new
drug, which is to effectively treat patients and minimize the chance of exposing
them to subtherapeutic or overly toxic doses. The prominent advantage of the
BOIN design is that it achieves simplicity and superior performance at the same
time. The BOIN design is algorithm-based and can be implemented in a simple
way similar to the traditional 3+3 design. The BOIN design yields an average
performance that is comparable to that of the continual reassessment method
(CRM, one of the best model-based designs) in terms of selecting the MTD, but
has a substantially lower risk of assigning patients to subtherapeutic or overly
toxic doses. For tutorial, please check Yan et al. (2020) .
How to cite:
Ying Yuan (2014). BOIN: Bayesian Optimal INterval (BOIN) Design for Single-Agent and Drug- Combination Phase I Clinical Trials. R package version 2.7.2, https://cran.r-project.org/web/packages/BOIN. Accessed 29 Apr. 2025.
Previous versions and publish date:
1.0 (2014-09-19 17:28), 1.1 (2015-02-15 07:35), 1.2 (2015-07-28 00:19), 2.0 (2015-09-04 21:49), 2.1 (2016-03-02 01:44), 2.2 (2016-04-22 08:40), 2.3 (2016-05-29 21:29), 2.4 (2016-08-09 01:37), 2.6.1 (2018-03-16 19:04), 2.6.2 (2018-03-27 09:24), 2.6.3 (2018-04-10 17:39), 2.6.4 (2018-10-12 23:50), 2.6.5 (2020-05-20 19:20), 2.6.6 (2020-05-23 08:50), 2.6.7 (2020-06-06 19:30), 2.6.8 (2020-06-30 07:00), 2.6.9 (2020-09-01 11:50), 2.6 (2018-02-21 19:09), 2.7.0 (2020-09-29 10:30), 2.7.1 (2020-11-19 23:20)
Other packages that cited BOIN R package
View BOIN citation profile
Other R packages that BOIN depends,
imports, suggests or enhances
Complete documentation for BOIN
Functions, R codes and Examples using
the BOIN R package
Some associated functions: get.boundary . get.oc.comb . get.oc . next.comb . next.subtrial . plot.boin . print.boin . select.mtd.comb . select.mtd . summary.boin .
Some associated R codes: get.boundary.R . get.oc.R . get.oc.comb.R . next.comb.R . next.subtrial.R . plot.boin.R . print.boin.R . select.mtd.R . select.mtd.comb.R . summary.boin.R . Full BOIN package functions and examples
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