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ActiveDriver  

Finding Cancer Driver Proteins with Enriched Mutations in Post-Translational Modification Sites
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Download and install ActiveDriver package within the R console
Install from CRAN:
install.packages("ActiveDriver")

Install from Github:
library("remotes")
install_github("cran/ActiveDriver")

Install by package version:
library("remotes")
install_version("ActiveDriver", "1.0.0")



Attach the package and use:
library("ActiveDriver")
Maintained by
Juri Reimand
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2017-08-23
Latest Update: 2017-08-23
Description:
A mutation analysis tool that discovers cancer driver genes with frequent mutations in protein signalling sites such as post-translational modifications (phosphorylation, ubiquitination, etc). The Poisson generalised linear regression model identifies genes where cancer mutations in signalling sites are more frequent than expected from the sequence of the entire gene. Integration of mutations with signalling information helps find new driver genes and propose candidate mechanisms to known drivers. Reference: Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers. Juri Reimand and Gary D Bader. Molecular Systems Biology (2013) 9:637 .
How to cite:
Juri Reimand (2017). ActiveDriver: Finding Cancer Driver Proteins with Enriched Mutations in Post-Translational Modification Sites. R package version 1.0.0, https://cran.r-project.org/web/packages/ActiveDriver. Accessed 21 Nov. 2024.
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Complete documentation for ActiveDriver
Functions, R codes and Examples using the ActiveDriver R package
Some associated functions: ActiveDriver . kinase_domains . mutations . phosphosites . read_fasta . sequence_disorder . sequences . 
Some associated R codes: ActiveDriver.R .  Full ActiveDriver package functions and examples
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