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AHTauDesign  

Truncation Time Selection for Average Hazard Analyses
View on CRAN: Click here


Download and install AHTauDesign package within the R console
Install from CRAN:
install.packages("AHTauDesign")

Install from Github:
library("remotes")
install_github("cran/AHTauDesign")

Install by package version:
library("remotes")
install_version("AHTauDesign", "0.1.0")



Attach the package and use:
library("AHTauDesign")
Maintained by
Xinyue Zhao
[Scholar Profile | Author Map]
All associated links for this package
First Published: 2026-09-10
Latest Update: 2026-09-10
Description:
Implements a two-stage, design-informed framework for selecting the truncation time in time-to-event trials analyzed with the average hazard estimand, motivated by pediatric oncology settings with small samples, slow accrual, and limited follow-up. Stage 1 validates a clinically proposed truncation time against the planned design using simulation-based diagnostics for risk-set support, follow-up coverage, estimability, and estimator stability, classifying it as Pass, Borderline, or Fail. Stage 2 performs constrained optimization over a grid of candidate truncation times within a clinical-distance window, maximizing a utility subject to feasibility constraints, with an independent evaluation run to assess the selected time. Supports proportional-hazards, early-, and delayed-effect patterns, uniform accrual with administrative censoring, and calibrated exponential random censoring.
How to cite:
Xinyue Zhao (2026). AHTauDesign: Truncation Time Selection for Average Hazard Analyses. R package version 0.1.0, https://cran.r-project.org/web/packages/AHTauDesign. Accessed 24 Oct. 2026.
Previous versions and publish date:
0.1.0 (2026-09-10 10:40), (2026-10-18 13:01)
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Complete documentation for AHTauDesign
Functions, R codes and Examples using the AHTauDesign R package
Full AHTauDesign package functions and examples
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